It is uncertain what the question means by the “same room” in an API facility.
Section 4.1 states that facilities should be designed to minimize potential contamination and cross
contamination. That’s the intent. There is no reason why you could not have different processes
or different intermediates or APIs processed side-by-side in closed reactors.
Obviously, a packaging operation is a different scenario. Having side-by-side packaging
operations without some sort of a barrier or containment between the lines is not an acceptable
GMP practice. The intent is to minimize cross contamination from one process to another.