Dietary supplement manufacturers must ensure that their products contain at least the labeled amount for each of the ingredients up until the expiration date (if there is an expiration date listed). As some ingredients in dietary supplements, such as vitamins, can naturally lose activity and or potency over time, dietary supplement manufacturers may need to increase the amount of the ingredient they add at the time of manufacturing to maintain compliance with the law. As is true for all dietary supplements, the manufacturer is responsible for ensuring that the product is safe.