Are facilities that manufacture gum base substances, such as polyvinyl acetate used to produce chewing gum base, required to register?

Yes. Chewing gum is “food” (section 201(f)(2) of the FD&C Act; 21 CFR 1.227). Because
polyvinyl acetate chewing gum base is an ingredient (component) of chewing gum, a facility that
manufactures/processes, packs, or holds it is required to register, unless the facility is exempt
from registration under 21 CFR 1.226.