Yes. A foreign facility’s emergency contact may have a phone number outside the United States.
However, the facility is also required to identify a U.S. agent who resides or maintains a place of
business in the United States and is physically located in the United States. The U.S. agent must
have a U.S. phone number. In addition, 21 CFR 1.232(c) requires an e-mail address for the U.S.
agent be provided in the foreign facility’s registration.