FDA’s regulations in 21 CFR include several lists of substances that are used in food on the
basis of the GRAS provision (see Table 5 and Table 6). Importantly, these lists are not all inclusive.
Because the use of a GRAS substance is not subject to premarket review and
approval by FDA, it is impracticable to list all substances that are used in food on the basis of
the GRAS provision.
