Unless you have something special in your filing that would allow for blending of the subpotent
material, than it would subject to what Q7A says about needing to meet specification. You set the
specification, so if it is a special case, than you probably have something either in your
specification or your filing for that.
It is fairly common for chromatographic purification that the first fractions are going to be much
purer than the final ones. Therefore, manufacturers have in process controls that the final
fraction(s) coming off are below the specification that the pooled material is going to have, but
that would be in their filing.