Well, not so long ago, I would have said, “part 11 compliant system, prints the number of print outs, then ok to shred if not needed.” Now, I would advise having an SOP that describes what, how, and who may shred any unwanted printouts, and that the analyst who prints such a document, writes on it why they believe it can be shredded. For example, the printer got stuck. Then it should get sent to Quality Unit for their review before getting shredded – that’s a controlled procedure. Certainly the practices that I have seen of stacks of unwanted printouts in the lab being used as scrap paper raises serious concerns as to the ease with which copies are generated.