Based on FDA changing of the meaning of “should”, does this mean that Q7A will be applied differently in the US than in the EU?

No. The change was made by FDA’s attorneys to comply with Good Guidance Practices. There
was no change in meaning intended. The change in the definition of “should,” was not intended to
have any impact on how the guidance is applied either domestically or abroad. Remember, Q7A
is a guidance document, but it is not legally binding to either the FDA or the public.