Generally in cleaning validation you are attempting to remove residues of the compound
previously manufactured in the equipment and cleaning agents, if these are used.
The objective is to look for compound residuals that shouldn’t be in the next intermediate or API.
Anything that you don’t expect to be there is what you’re trying to find and remove from the
equipment. Obviously, if you don’t use cleaning agents, then testing for cleaning agents would not
be an issue. However, if a company uses a solvent as a final rinse for a piece of equipment, and
that same solvent is used in the next process step, they would not be expected to test for
residuals of this solvent.
