The final rule does not identify specific in-process testing that must be performed. However, under the new rule you are required to set (21 CFR 111.70) and monitor (21 CFR 111.75) in-process specifications for any point, step, or stage in the manufacturing process (documented in the master manufacturing record) where control is necessary and for limits on those types of contamination that may adulterate or lead to adulteration of your finished dietary supplement products.