Carryover of centrifuge heel is not considered blending. That is typically considered carry over of
material from one batch to another.
This carryover is typically handled during process validation. You look at the amount of material
that’s left in the centrifuge, and then depending on the product and how stable it is under
centrifuge conditions, it may make sense to take a sample of the centrifuge heel during validation
and look at the impurities. That is normally covered in validation and your development and
engineering people need to help you set up.
