This is a great question. Change control relates to making modifications to the system. So, unlike protocols, that go through an annual review, systems should be validated or revalidated when there are significant changes. There may be minor modifications such as minor tweaks such as fixing bugs that don’t warrant full revalidation; whereas new features or critical updates would require revalidation or validation of those new components. So, I wouldn’t view it from an annual basis perspective. It’s really about the system, confirming integrity of the system, and if there are any changes, those changes are tested prior to implementation.