Benefits Clinical trials that are well-designed and well-executed are the best treatment approach for eligible participants to: -Play an active role in their own health care -Gain access to new research treatments before they are widely available -Obtain expert medical care at leading health care facilities during the trial -Help others by contributing to medical research Risks There are risks to participating in a clinical trial. There may be unpleasant, serious or even life-threatening side effects to treatment -The treatment may not be effective for the participant. -The protocol may require more of their time and attention than would a non-protocol treatment, including trips to the study site, more treatments, hospital stays or complex dosage requirements.